Three Cases of Leptomeningeal Carcinomatosis from Lung Adenocarcinoma Responding to EGFR TKIs
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چکیده
منابع مشابه
Successful osimertinib treatment for leptomeningeal carcinomatosis from lung adenocarcinoma with the T790M mutation of EGFR
Osimertinib is a third-generation tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR) that has been approved for the treatment of metastatic non-small cell lung cancer (NSCLC) positive for the secondary T790M mutation of EGFR. In a preclinical study, it also showed efficacy against leptomeningeal carcinomatosis (LMC) derived from NSCLC resistant to first-generation an...
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Pulmonary lymphangitic carcinomatosis is the spread of a tumor to the lungs through the lymphatic system, which is a rare and final manifestation of cancer with a poor prognosis. Its main symptom is gradual and progressive dyspnea. The method of choice for diagnosis is high-resolution CT (HRCT), the most common finding of which is an increase in nodular and irregular septal thickness between th...
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This study aimed to elucidate the association of the content of mutant epidermal growth factor receptor (EGFR) deoxyribonucleic acid (DNA) with the treatment response to EGFR-tyrosine kinase inhibitor (TKI) and survival in patients with lung cancer.This retrospective cohort study included 77 lung adenocarcinoma patients with common EGFR mutations from December 2012 to February 2015. The content...
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Leptomeningeal carcinomatosis occurred in an old female patient who was on a standard dose of afatinib for the treatment of her non-small cell lung cancer harboring an epidermal growth factor receptor gene mutation sensitive to tyrosine kinase inhibitors when extracranial lesions were still under control. Shifting to high-dose, pulsatile erlotinib dramatically saved her from the devastating con...
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Leptomeningeal carcinomatosis (LC) is a metastatic cancer invading the central nervous system (CNS). We previously reported a metabolomic diagnostic approach as tested on an animal model and compared with current modalities. Here, we provide a proof of concept by applying it to human LC originating from lung cancer, the most common cause of CNS metastasis. Cerebrospinal fluid from LC (n = 26) a...
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ژورنال
عنوان ژورنال: Haigan
سال: 2009
ISSN: 1348-9992,0386-9628
DOI: 10.2482/haigan.49.461